Alpha-Methyldopa Sesquihydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

α-甲基多巴倍半水合物是一种多巴脱羧酶抑制剂和间接α2-肾上腺素受体激动剂，用于治疗高血压。它抑制交感神经系统，减少多巴胺、去甲肾上腺素和肾上腺素的产生，并表现出一氧化氮依赖性镇静活性。

Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.(In Vivo):Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment.

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Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. Animal Model:60-day-old male rats Dosage:200 mg/kg Administration: i.p.Result:Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

MK-351 hydrate | Methyldopa hydrate | Methyldopa Sesquihydrate | L-(-)-α-Methyldopa hydrate

GPCR/G Protein

Dopamine Receptor

DOPA decarboxylase

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41372-08-1

238.24

C10H13NO4·3/2H?O

>98% (HPLC)

DMSO:33.33 mg/mL (139.90 mM)

O.O.O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O

(S)-2-amino-3-(34-dihydroxyphenyl)-2-methylpropanoic acid sesquihydrate

(-20℃)

With Ice Pack

≥ 2 years