Ropinirole hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ropinirole 是一种选择性多巴胺 D2 受体激动剂，Ki 为 29 nM。

Ropinirole a selective dopamine D2 receptors agonist with Ki of 29 nM.(In Vitro):Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors.(In Vivo):Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.

Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors.

Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory. Animal Model:Male Sprague–Dawley rats weighing 220-350 g Dosage:0.1, 1 or 10 mg/kg Administration:i.p.Result:Decreased ICSS thresholds and induced anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.

SKF 101468A

GPCR/G Protein

Dopamine Receptor

D2

Neurological Disease

——

91374-20-8

296.84

C16H24N2O·HCl

>98% (HPLC)

Water: 60 mg/mL (202.12 mM); DMSO: 10 mg/mL (33.68 mM)

O=C(NC/1=O)SC1=C\C2=CC=C(OCO3)C3=C2

5-(Benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

(-20℃)

With Ice Pack

≥ 2 years