LUPENONE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

羽扇豆酮是从芭蕉中分离出来的天然产物，具有良好的抗糖尿病活性，并具有抗炎活性。羽扇豆酮是有效的 PTP1B 抑制剂，IC50 值为 15.11±1.23μM。

Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activityand has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 values of 15.11±1.23μM.

Cell Viability Assay Cell Line:SH-SY5yConcentration:5, 10. 20, 40 μM Incubation Time:24 h Result:Did not cause significant cell death at different concentrations.Apoptosis Analysis Cell Line:SH-SY5y Concentration:40 μM Incubation Time:1 hResult:Reduced the population of annexinV/PI-positive cells (early apoptotic cells) and annexinV positive cells (total apoptotic cells).Western Blot Analysis Cell Line:SH-SY5y Concentration:40 μM Incubation Time:1 h Result:Increased the expression of anti-apoptotic proteins, including bcl-2 and caspases such as caspase 3, caspase 7, and caspase 8.Recuperate the phosphorylation level of PI3K and Akt.Inhibited the translocation of p65 from the cytosol to the nucleus, IκBα degradation, and IκBα phosphorylation.

Animal Model:Spontaneous type 2 diabetic nephropathy db/db mouse models Dosage:6, 12, 24 mg/kg Administration:i.g.Result:Maintained the fasting blood glucose.Reduced glycosylated hemoglobin, insulin, and 24 h proteinuria levels.Regulated changes in biochemical indicators

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Metabolic Enzyme/Protease

Phosphatase

PTP1B

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1617-70-5

424.7

C30H48O

>98% (HPLC)

In Vitro:?Ethanol : 10 mg/mL (23.55 mM)

[H][C@]12[C@@H](CC[C@]1(C)CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CCC(=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(C)=C

Lup-20(29)-en-3-one

(-20℃)

With Ice Pack

≥ 2 years