CGP71683 hydrochloride ( CGP71683A )

产品货号. M20256 CAS No. 192322-50-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CGP71683 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CGP71683 是一种竞争性神经肽 Y5 受体拮抗剂 (Ki: 1.3 nM)，对细胞膜中的 Y1 受体 (Ki >4000 nM) 和 Y2 受体 (Ki: 200 nM) 无明显活性。
产品描述

CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
体外实验

CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
体内实验

CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats.
同义词

CGP71683A
通路

GPCR/G Protein
靶点

Neuropeptide Y Receptor
受体

Y5 receptor
研究领域

——
适应症

——

1.Lecklin A et al. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37.

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