CGP71683 hydrochloride ( CGP71683A )

产品货号. M20256 CAS No. 192322-50-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

CGP71683 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CGP71683 是一种竞争性神经肽 Y5 受体拮抗剂 (Ki: 1.3 nM)，对细胞膜中的 Y1 受体 (Ki >4000 nM) 和 Y2 受体 (Ki: 200 nM) 无明显活性。
产品描述

CGP71683 is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes.
体外实验

CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
体内实验

CGP71683 (15 nmol/rat, icv, twice daily) shows anorexigenic effect, reducing food intake and bady weight of fed rats. CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats.
同义词

CGP71683A
通路

GPCR/G Protein
靶点

Neuropeptide Y Receptor
受体

Y5 receptor
研究领域

——
适应症

——

1.Lecklin A et al. Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br J Pharmacol. 2002 Apr;135(8):2029-37.

计算器

产品手册

关联产品

GALNON TFA(475115-35...

Galnon 是一种新型非肽甘丙肽受体激动剂（GAL1 和 GAL2 Ki 分别为 11.7 和 34.1 μM）。
SF-22

SF-22 is a neuropeptide Y receptor (Y2R) antagonist that crosses the blood-brain barrier and has potential anti-inflammatory activity for the study of diseases associated with neurological disorders.
M871

Selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.