SRI 31215

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SRI 31215 是一种小分子，可作为 matriptase、hepsin 和 HGFA 的三联抑制剂，并模拟 HAI-1/2（HGF 激活的内源性抑制剂）的活性，IC50 分别为 0.69 μM、0.65 μM、0.3 μM。

SRI 31215 a small molecule that acts as a triplex inhibitor of matriptase hepsin and HGFA and mimics the activity of HAI-1/2 endogenous inhibitors of HGF activation with IC50s of 0.69 μM 0.65 μM 0.3 μM

Western Blot Analysis Cell Line:DU145 cells Concentration:10 μM Incubation Time:30 min Result:Prevented fibroblast-induced MET activation and signaling in tumor cells, but did not prevent MET activation induced by active HGF.Cell Migration Assay Cell Line:DU145 cells Concentration:10 μM Incubation Time:24 h Result:Did not interfere with HGF-induced migration, but inhibited fibroblast-induced migration of DU145 cells.

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Angiogenesis

c-Met/HGFR

HGFA|matriptase|hepsin

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1832686-44-8

533.6

C27H34F3N5O3

>98% (HPLC)

DMSO:Soluble

OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC1CN(CC2CCN(Cc3ccccc3)CC2)C(=O)N(C1)c1cccc(c1)C(N)=N

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(-20℃)

With Ice Pack

≥ 2 years