SOMG-833 ( SOMG 833 | SOMG833 )

产品货号. M11122 CAS No. 1268264-10-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SOMG-833
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种有效的、选择性的 ATP 竞争性 c-MET 抑制剂，IC50 为 0.93 nM。
产品描述

A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo.
体外实验

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体内实验

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同义词

SOMG 833 | SOMG833
通路

Angiogenesis
靶点

c-Met/HGFR
受体

c-Met/HGFR
研究领域

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适应症

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CAS Number

1268264-10-3
分子量

445.446
分子式

C22H22F3N5O2
纯度

>98% (HPLC)
溶解度

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SMILES

CN1CCN(CC1)C2=CC3=C(C=C(C=C3NCC4=CC(=CC=C4)[N+](=O)[O-])C(F)(F)F)N=C2
化学全称

3-(4-methylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl) quinoline