Ansofaxine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ansofaxine (LY03005; LPM570065) 是一种血清素-去甲肾上腺素-多巴胺再摄取抑制剂（IC50 分别为：723、763 和 491 nM）。

Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723 763 and 491 nM respectively).(In Vivo):Ansofaxine rapidly penetrates the rat striatum, converts into desvenlafaxine and exhibits larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of ansofaxine increases the 5-HT, dopamine and norepinephrine levels more than the relative administration of desvenlafaxine. Unlike desvenlafaxine, acute administration of an intravenous ansofaxine solution does not induce the undesirable 90% decrease in extracellular 5-HT levels. The acute administration of ansofaxine shows a capped increase in extracellular 5-HT levels when combined with WAY-100635. Acute and chronic administration of ansofaxine reduces the immobility time more than the relative administration of desvenlafaxine.

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Ansofaxine rapidly penetrates the rat striatum, converts into desvenlafaxine and exhibits larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of ansofaxine increases the 5-HT, dopamine and norepinephrine levels more than the relative administration of desvenlafaxine. Unlike desvenlafaxine, acute administration of an intravenous ansofaxine solution does not induce the undesirable 90% decrease in extracellular 5-HT levels. The acute administration of ansofaxine shows a capped increase in extracellular 5-HT levels when combined with WAY-100635. Acute and chronic administration of ansofaxine reduces the immobility time more than the relative administration of desvenlafaxine.

LY03005 | LPM570065

Endocrinology/Hormones

5-HT Receptor

serotonin reuptake| dopamine reuptake| norepinephrine reuptake

Neurological Disease

Major depressive disorder

916918-84-8

417.97

C24H32ClNO3

>98% (HPLC)

DMSO: 30 mg/mL (71.77 mM)

Cl.CN(C)CC(c1ccc(OC(=O)c2ccc(C)cc2)cc1)C1(O)CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years