T-26c

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

T-26c 是高效且选择性的基质金属蛋白酶-13 (MMP-13) 抑制剂 (IC50: 6.75 pM)。

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor (IC50: 6.75 pM).(In Vitro):T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage.(In Vivo):T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL).

T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage.

T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL).

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Metabolic Enzyme/Protease

MMP

MMP-13

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869296-13-9

479.51

C24H21N3O6S

>98% (HPLC)

DMSO: 12 mg/mL (25.03 mM);Water: Insoluble

COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(cc4)C(O)=O)c3c(=O)[nH]2)c1

4-(((2-((3-methoxybenzyl)carbamoyl)-4-oxo-34-dihydrothieno[23-d]pyrimidin-5-yl)methoxy)methyl)benzoic acid

(-20℃)

With Ice Pack

≥ 2 years