S-methyl-KE-298

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

S-甲基-KE-298 是血浆中的第二个主要代谢物，是脱乙酰基-KE-298 的甲基缀合物。KE-298 抑制类风湿性关节炎 (RA) 滑膜细胞产生基质金属蛋白酶 (MMP-1)。

S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from ?rheumatoid arthritis (RA) synovial cells.

S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production fromrheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells.

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Metabolic Enzyme/Protease

MMP

MMP-1

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143584-75-2

252.33

C13H16O3S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (396.31 mM)

CSCC(C(O)=O)CC(C1=CC=C(C)C=C1)=O

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(-20℃)

With Ice Pack

≥ 2 years