Sobetirome

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sobetirome 是甲状腺激素受体 β (TRβ) 的选择性激动剂，选择性结合 TRβ-1 (EC50: 0.16 μM)。

Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).(In Vivo):Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20%.

——

Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20% (1.3 g).

QRX-431 | IACS-010759

Endocrinology/Hormones

THR

TRβ

Others

Adrenoleucodystrophy

211110-63-3

328.4

C20H24O4

>98% (HPLC)

DMSO: 30 mg/mL (91.4 mM);Ethanol: 30 mg/mL

CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O

2-(4-(4-hydroxy-3-isopropylbenzyl)-35-dimethylphenoxy)acetic acid

(-20℃)

With Ice Pack

≥ 2 years