C176

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

C-176 是一种高效的共价小鼠 STING 抑制剂。

C-176 is a highly potent and covalent mouse STING inhibitor.(In Vitro):C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.(In Vivo):C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1?/? mice.C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1?/? mice.

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.

C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1?/? mice.C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1?/? mice. Animal Model:WT type mice.Dosage:750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).Administration:Intraperitoneally, once.Result:Significantly reduced Serum levels of type I IFNs and IL-6.

C 176 | C-176 | STING inhibitor 1

Immunology/Inflammation

STING

STING

——

——

314054-00-7

358.09

C11H7IN2O4

>98% (HPLC)

DMSO: 100 mg/mL

[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc(I)cc1

N-(4-iodophenyl)-5-nitrofuran-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years