Erucic acid

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在发育退化的自闭症受试者的红细胞膜中发现芥酸 (22:1n9) 水平升高。

Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia which is an inborn error of metabolism.

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Erucic acid (oral administration; 3 mg/kg) enhances the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus compared with that in the vehicle-treated control group. Animal Model:Normal na?ve mice Dosage:3 mg/kg Administration:Oral administration; 3 mg/kg Result:Enhanced the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus.

cis-13-docosenoic acid | 13(Z)-Docosenoic Acid | Prifac 2990

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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112-86-7

338.57

C22H42O2

>98% (HPLC)

DMSO:197.9 mM

CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years