Erucic acid ( cis-13-docosenoic acid | 13(Z)-Docosenoic Acid | Prifac 2990 )

产品货号. M19744 CAS No. 112-86-7

在发育退化的自闭症受试者的红细胞膜中发现芥酸 (22:1n9) 水平升高。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
10MG	￥138	有现货
25MG	￥197	有现货
50MG	￥272	有现货
100MG	￥374	有现货
500MG	￥887	有现货
1G	￥1305	有现货
1 mL x 10 mM in DMSO	￥443	有现货

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生物学信息

产品名称

Erucic acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

在发育退化的自闭症受试者的红细胞膜中发现芥酸 (22:1n9) 水平升高。
产品描述

Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia which is an inborn error of metabolism.
体外实验

——
体内实验

Erucic acid (oral administration; 3 mg/kg) enhances the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus compared with that in the vehicle-treated control group. Animal Model:Normal na?ve mice Dosage:3 mg/kg Administration:Oral administration; 3 mg/kg Result:Enhanced the phosphorylation level of PI3K, PKCζ, ERK, CREB and Akt in the hippocampus.
同义词

cis-13-docosenoic acid | 13(Z)-Docosenoic Acid | Prifac 2990
通路

Proteasome/Ubiquitin
靶点

Endogenous Metabolite
受体

Human Endogenous Metabolite
研究领域

——
适应症

——

化学信息

CAS Number

112-86-7
分子量

338.57
分子式

C22H42O2
纯度

>98% (HPLC)
溶解度

DMSO:197.9 mM
SMILES

CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Aubourg P Adamsbaum C Lavallardrousseau M C et al. A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy.[J]. New England Journal of Medicine 1993 329(11):745.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册