Ercalcidiol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Er骨化醇是维生素 D2 的代谢产物，可用于监测维生素 D 治疗。

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.(In Vitro):The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and Ercalcidiol binds less well to the vitamin D binding protein, making Ercalcidiol less potent and required much higher doses than vitamin D3 .

Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2.

——

25-hydroxy Vitamin D2

Proteasome/Ubiquitin

Endogenous Metabolite

RUVBL1/2

——

——

21343-40-8

412.658

C28H44O2

>98% (HPLC)

In Vitro:?DMSO : 200 mg/mL (484.67 mM)

[H][C@@]12CC[C@H]([C@H](C)\C=C\[C@H](C)C(C)(C)O)[C@@]1(C)CCC\C2=C/C=C1/C[C@@H](O)CCC1=C

——

(-20℃)

With Ice Pack

≥ 2 years