Phenylacetic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

乙酸苯酯（或苯乙酸酯）是一种羧酸酯，已在肾炎和/或肝炎患者以及苯丙酮尿症 (PKU)（一种先天性代谢缺陷）患者的生物体液中发现。体内过量的苯丙氨酸可以通过氨基转移过程处理掉，从而产生苯丙酮酸。

Phenyl acetate (or phenylacetate) is a carboxylic acid ester that has been found in the biofluids of patients with nephritis and/or hepatitis as well as patients with phenylketonuria (PKU) an inborn error of metabolism. Excess phenylalanine in the body can be disposed of through a transamination process leading to the production of phenylpyruvate. The phenylpyruvate can be further metabolized into a number of products. Decarboxylation of phenylpyruvate gives phenylacetate while a reduction reaction gives phenyllactate. The phenylacetate can be further conjugated with glutamine to give phenylacetyl glutamine. All of these metabolites can be detected in serum and urine of PKU patients. Phenyl acetate is also produced endogenously as the metabolite of 2-Phenylethylamine which is mainly metabolized by monoamine oxidase to form phenyl acetate. 2-phenylethylamine is an "endogenous amphetamine" which may modulate central adrenergic functions and the urinary phenyl acetate levels have been postulated as a marker for depression. Phenylacetate is also found in essential oils e.g. neroli rose oil free and as esters' and in many fruits. As a result it is used as a perfumery and flavoring ingredient.

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Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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103-82-2

136.15

C8H8O2

>98% (HPLC)

DMSO:10 mM

OC(=O)Cc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years