L-(-)-Malic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

苹果酸是一种具有酸味的有机二羧酸，在许多酸味或酸味食物中发挥作用。苹果含有苹果酸，它导致了青苹果的酸味。苹果酸可以使葡萄酒尝起来酸涩，尽管苹果酸的含量随着水果成熟度的增加而减少。

Malic acid is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid which contributes to the sourness of a green apple. Malic acid can make a wine taste tart although the amount decreases with increasing fruit ripeness. (wikipedia). In its ionized form malic acid is called malate. Malate is an intermediate of the TCA cycle along with fumarate. It can also be formed from pyruvate as one of the anaplerotic reactions. In humans malic acid is both derived from food sources and synthesized in the body through the citric acid cycle or Krebs cycle which takes place in the mitochondria. Malate's importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malate-aspartate redox shuttle. During anaerobic conditions where a buildup of excess of reducing equivalents inhibits glycolysis malic acid's simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxia's inhibition of glycolysis and energy production. In studies on rats it has been found that only tissue malate is depleted following exhaustive physical activity. Other key metabolites from the citric acid cycle needed for energy production were found to be unchanged. Because of this a deficiency of malic acid has been hypothesized to be a major cause of physical exhaustion. Notably the administration of malic acid to rats has been shown to elevate mitochondrial malate and increase mitochondrial respiration and energy production.

It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L. casei. Furthermore, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose, whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose.

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(S)-2-Hydroxysuccinic acid | (S)-(-)-HYDROXYSUCCINIC ACID

Proteasome/Ubiquitin

Endogenous Metabolite

others

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97-67-6

134.09

C4H6O5

>98% (HPLC)

DMSO: 10 mM

O[C@@H](CC(O)=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years