Platycodin D

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Platycodin D 可能刺激 TNF-α 合成或抑制 TNF-α mRNA 降解。 Platycodin D (10/30 μM) 可抑制由蛋白激酶 C 激活剂 12-O-十四烷酰佛波醇 13-乙酸酯 (TPA) 刺激的大鼠腹膜巨噬细胞中前列腺素 E2 的产生。

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.

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Animal Model:Genetically obese db/db mice Dosage:5 mg/kg Administration:Oral administration; 5 mg/kg, 5 times per week for 5 weeks Result:Significantly decreased body weight gain without affecting food intake of mice. Decreased the liver tissue weight and increased the weight of brown adipose tissue (BAT).

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Endocrinology/Hormones

AChR

PGE2

Others-Field

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58479-68-8

1225.34

C57H92O28

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (40.81 mM)

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(-20℃)

With Ice Pack

≥ 2 years