LY 334370

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LY334370 是一种选择性 5-HT1F 受体激动剂，Ki 为 1.6 nM。

LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM

LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10-5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant.

Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actualdural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg).

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Endocrinology/Hormones

AChR

5-HT1F

Neurological Disease

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182563-08-2

351.42

C21H22FN3O

>98% (HPLC)

DMSO : ≥ 55.5 mg/mL; 157.93 mM

O=C(NC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)C4=CC=C(F)C=C4

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(-20℃)

With Ice Pack

≥ 2 years