Prunetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Prunetin 显着降低脂多糖攻击小鼠的血清炎症细胞因子水平和死亡率。

Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.

Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5?AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells.

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Others

Other Targets

NF-κB|ERK

Others-Field

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552-59-0

284.26

C16H12O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (351.79 mM)

COC1=CC(=C2C(=C1)OC=C(C2=O)C3=CC=C(C=C3)O)O

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(-20℃)

With Ice Pack

≥ 2 years