Scopolin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Scopolin 可通过抑制炎症和血管生成来减轻大鼠 AIA 的临床症状，该化合物可能是治疗血管生成相关疾病的有效化合物，并可作为筛选更有效的合成类似物的结构基础。

Scopolin formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.

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Animal Model:HFD-fed C57BL/6?N miceDosage:0.02% (w/w) in HFD diet (equivalent to 20?mg/kg body weight)Administration:Supplemented in diet, 8 weeks Result:Reversed the HFD-induced hepatic TG, cholesterol, and fatty acid accumulation by 35%, 49%, and 35%, respectively.Reversed the HFD-induced decrease in plasma adiponectin levels by 76%, and reduced the increased plasma MCP-1, TNFα, and IL-6 levels.Restored HFD-induced downregulation of SIRT1 activity.Animal Model:Adjuvant-induced arthritis (AIA) rats Dosage:50, 100 mg/kg Administration:i.p.Result:Inhibited inoculated and non-inoculated paw swelling and articular index scores.Reduced new blood vessels, and reduced IL-6, VEGF and FGF-2 expressions in rat synovial tissues.

Scopolin | Murrayin | Scopoloside

Apoptosis

NF-κB

Others

Inflammation/Immunology

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531-44-2

354.31

C16H18O9

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (282.24 mM)

COc1c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)cc2oc(=O)ccc2c1

6-methoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one

(-20℃)

With Ice Pack

≥ 2 years