Plumbagin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

白花丹素是一种黄色染料，正式衍生自萘醌。它以最初分离的白花属植物命名。

Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe.(In Vitro):Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner.Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells.(In Vivo):Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice.Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice.

Apoptosis Analysis Cell Line:DU145, CWR22rv1, LNCaP and RWPE-1 cells Concentration:0, 5, 10, and 15 μM Incubation Time:24 hours Result:Dose-dependently induced apoptosis of DU145, CWR22rv1 and LNCaP, but showed no effect on RWPE-1 cells at up to 20 μM.

Animal Model:Male athymic nude mice bearing DU145 cells Dosage:2 mg/kg Administration:I.P. after 3 days post cell implantation, five days a week. Result:Delayed tumor growth by 3 weeks, and reduced tumor weight and volume in mice.

Plumbagin

Others

Other Targets

ROS

Cancer

——

481-42-5

188.18

C11H8O3

>98% (HPLC)

DMSO : ≥ 150 mg/mL 797.11 mM H2O : < 0.1 mg/mL

CC1=CC(=O)c2c(C1=O)cccc2O

5-Hydroxy-2-methylnaphthalene-1,4-dione

(-20℃)

With Ice Pack

≥ 2 years