Gentiopicrin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gentiopicroside 是一种天然存在的环烯醚萜苷，从 Gentiana manshurica Kitag 中提取，可抑制 P450 活性，对 CYP2A6 的 IC50 和 Ki 分别为 61 μM 和 22.8 μM。

Gentiopicrin is found in gentiana and cephalaria. It displays many biological properties, including suppressing expression of NMDA receptors in the anterior cingulate cortex, inhibiting morphine conditioned place preference, and preventing arachidonic acid and PMA-induced superoxide generation.

Gentiopicroside inhibits P450 activity, with an IC50 and a Ki of 61 μM and 8.12 μM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50?μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50?μM) also inhibits RANKL-induced bone resorption.

Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.

O673 | O-673 | O 673 | SC-46058

Others

Other Targets

Others

Others-Field

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20831-76-9

356.33

C16H20O9

>98% (HPLC)

DMSO : ≥ 150 mg/mL; 420.97 mM

C=C[C@H]1[C@@H](OC=C2C1=CCOC2=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O

(5R,6S)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one

(-20℃)

With Ice Pack

≥ 2 years