Acetyl Coenzyme A trisodium

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Acetyl-coenzyme A (Acetyl-CoA) trisodium 是一种膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A trisodium 通过向目标氨基酸残基提供 (唯一供体) 乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A trisodium 也是脂质合成的关键前体。

Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis.

Acetyl coenzyme A trisodium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A trisodium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h).

Acetyl coenzyme A trisodium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy.Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A trisodium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A trisodium concentrations in the brain and actually increase hepatic Acetyl coenzyme A trisodium and protein acetylation levels.

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Others

Other Targets

OXPHOS | Endogenous Metabolite | Autophagy

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102029-73-2

875.52

C23H35N7Na3O17P3S

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 83.33 mg/mL (95.18 mM; 超声助溶) DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

O[C@H]1[C@@H](O[C@@H]([C@H]1OP([O-])([O-])=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(O)=O)([O-])=O)N2C3=NC=NC(N)=C3N=C2.[Na+].[Na+].[Na+]

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(-20℃)

With Ice Pack

≥ 2 years