C-DIM12 ( C-DIM12 | C-DIM 12 | C-DIM-12 )

产品货号. M18138 CAS No. 178946-89-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

C-DIM12
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

C-DIM12 增加了转染的人 Nurr1 的表达，诱导原代多巴胺能神经元中的 Nurr1 蛋白表达，并提高了暴露于 6-OHDA 后的神经元存活率。
产品描述

C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.
体外实验

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体内实验

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同义词

C-DIM12 | C-DIM 12 | C-DIM-12
通路

Others
靶点

Other Targets
受体

Nurr1 activator
研究领域

Neurological Disease
适应症

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1. Hammond SL, Safe S, Tjalkens RB. Neurosci Lett. 2015 Oct 21;607:83-9.

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