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Cerdulatinib hydrochloride
CAS No. 1369761-01-2
Cerdulatinib hydrochloride ( —— )
产品货号. M17977 CAS No. 1369761-01-2
Cerdulatinib (PRT-062070) 是一种口服活性、多靶点酪氨酸激酶抑制剂，对 JAK1/JAK2/JAK3/TYK2 和 Syk 的 IC50 分别为 12 nM/6 nM/8 nM/0.5 nM 和 32 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥306 | 有现货 |
|
| 10MG | ￥408 | 有现货 |
|
| 25MG | ￥658 | 有现货 |
|
| 50MG | ￥995 | 有现货 |
|
| 100MG | ￥1467 | 有现货 |
|
| 200MG | ￥2142 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Cerdulatinib hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Cerdulatinib (PRT-062070) 是一种口服活性、多靶点酪氨酸激酶抑制剂，对 JAK1/JAK2/JAK3/TYK2 和 Syk 的 IC50 分别为 12 nM/6 nM/8 nM/0.5 nM 和 32 nM。
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产品描述Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
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体外实验Cell Viability Assay Cell Line:SU-DHL4; SU-DHL6; Ramosand and Daudi cells Concentration:0, 1, 3 μM Incubation Time:48 hours Result:Inhibits cells viability with the IC50s of 0.73-1.39 μM.Apoptosis Analysis Cell Line:SU-DHL4, SU-DHL6, and Ramos cells Concentration:0, 1.6, 5.0, 15 μM Incubation Time:72 hours Result:Induced SU-DHL4, SU-DHL6, and Ramos cells apoptosis.
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体内实验Animal Model:Female Lewis rats (7-8 weeks old; 159-187 g) are immunizedDosage:0, 0.5, 1.5, 3, 5?mg/kg Administration:Oral gavage twice daily for 2 weeks Result:Modulated inflammation in the rat CIA treatment model.Affected anticollagen antibody formation.Animal Model:Balb/c mice are received BCR stimulation Dosage:0, 1, 5, 15, 20, 30?mg/kg Administration:Oral gavage twice daily for 5 days Result:Suppressed upregulation of splenic B-cell surface CD80/86 and CD69 by＞60%.Inhibited mouse splenomegaly in a dose- and concentration-dependent manner.
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同义词——
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通路Others
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靶点Other Targets
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受体c-Fms| MST1| ARK5| MLK1| Tyk2
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研究领域Cancer|Inflammation/Immunology
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适应症——
化学信息
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CAS Number1369761-01-2
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分子量482
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分子式C20H28ClN7O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 20 mg/mL (41.49 mM)
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SMILESCl.CCS(=O)(=O)N1CCN(CC1)C1=CC=C(NC2=NC(NC3CC3)=C(C=N2)C(N)=O)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Coffey G, J Pharmacol Exp Ther. 2014, 351(3), 538-548.
产品手册
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