Allopurinol Sodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Allopurinol Sodium 是一种黄嘌呤氧化酶抑制剂，IC50 为 7.82±0.12 μM。

Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.

Allopurinol sodium (0, 10, 100, 1000 μg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells.Allopurinol sodium (0, 10, 100, 1000 μg/ml; 24 h) reduces angiogenesis traits of HUVEC cells. Western Blot Analysis Cell Line:HFF, HUVEC cells Concentration:0, 10, 100, 1000 μg/ml Incubation Time:17 h Result:Reduced HIF-1α and HIF-2α protein expression in a dose dependent manner.

Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse.Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse. Animal Model:20-30 g, male Swiss Albino mice Dosage:39 mg/kg Administration:P.o.; daily for 21 successive days Result:Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.Animal Model:30-40 g, male adult Swiss albino mice Dosage:10, 50, 100, 200, 400 mg/kg Administration:I.p.Result:Produced dose-dependent anti-nociception in the tail-flick, hot-plate.

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Endocrinology/Hormones

5-HT Receptor

XO

Others-Field

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17795-21-0

159.1

C5H4N4NaO

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (314.27 mM)

[Na+].O=C1NC=NC2=C1C=NN2

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(-20℃)

With Ice Pack

≥ 2 years