Pyridostatin TFA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pyridostatin Trifluacetate Salt 是一种 G-四链体稳定剂，在无细胞测定中 Kd 为 490 nM，靶向一系列原癌基因，包括 c-kit、K-ras 和 Bcl-2。

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin TFA is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin TFA causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin TFA induces the formation of DNA DSBs. Remarkably, Pyridostatin TFA (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level. Cell Viability Assay Cell Line:Over 60 different cancer cell linesConcentration:10 μMIncubation Time:48 hoursResult:Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.

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Neuroscience

GluR

G-quadruplexe

Others-Field

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1472611-44-1

938.71

C37H35F9N8O11

>98% (HPLC)

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O=C(Nc1cc(OCCN)c2ccccc2n1)c3cc(OCCN)cc(n3)C(=O)Nc4cc(OCCN)c5ccccc5n4.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years