RG 14620 ( RG 14620 | TYRPHOSTIN RG 14620. )

产品货号. M17976 CAS No. 136831-49-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RG 14620
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RG14620 是一种表皮生长因子受体 (EGFR) 抑制剂。
产品描述

RG-14620 is an EGFR inhibitor. It is a non-phenolic tyrphostin analog, which is selective for the EGF receptor and long acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=3 μM) as well as tumor growth in vivo.
体外实验

RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible.
体内实验

RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals.
同义词

RG 14620 | TYRPHOSTIN RG 14620.
通路

Others
靶点

Other Targets
受体

HER14 colony formation| HER14 DNA synthesis
研究领域

Cancer
适应症

——

1. Yoneda T,et al. Cancer Res. 1991 Aug 15;51(16):4430-5.

计算器

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