Loureirin B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Loureirin B可以通过调节MMPs和TIMPs水平下调纤维化相关分子的表达，抑制疤痕成纤维细胞增殖，抑制TGF-β1诱导的纤维化，其中TGF-β1/Smad2/3通路可能参与其中。

Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathway is likely involved.

Loureirin B enhances the relative mRNA level of Pdx-1 and MafA. Loureirin B (1, 0.1, and 0.01?μM) increases insulin secretion in Ins-1 cells. Loureirin B (0.01?μM) almost causes no toxicity on cells. Loureirin B improves the level of expressions of MafA and Pdx-1 and ATP level. Loureirin B inhibits the KATP current but increases the [Ca2+]i level in Ins-1 cells. Loureirin B inhibits the expression of Col1 and FN, as well as the TGF-β1-mediated up regulation of p-JNK. Loureirin B also inhibits the up regulation of p-ERK that is induced by TGF-β1. Moreover, Loureirin B inhibits the contraction of TGF-β1-stimulated fibroblasts through the down regulation of p-ERK and p-JNK. However, Loureirin B does not suppress the up regulation of p-p38 that is induced by TGF-β1. Loureirin B downregulates both mRNA and protein levels of type I collagen, type III collagen and α-smooth muscle actin in a dose dependent manner in HS fibroblasts. Loureirin B also suppresses fibroblast proliferative activity and redistributes cell cycle, but does not affect cell apoptosis.

Loureirin B significantly improves the arrangement and deposition of collagen fibres, decreases protein levels of ColI, ColIII and α-SMA and suppresses myofibroblast differentiation and scar proliferative activity, in a rabbit ear scar model. Loureirin B effectively inhibits TGF-β1-induced upregulation of ColI, ColIII and α-SMA levels, myofibroblast differentiation and the activation of Smad2 and Smad3, in NS fibroblasts.

Loureirin B | LR-B | L B | LRB

Cell Cycle/DNA Damage

DNA/RNA Synthesis

Others

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119425-90-0

316.35

C18H20O5

>98% (HPLC)

DMSO : ≥ 150 mg/mL; 474.16 mM

COc1cc(c(c(c1)OC)CCC(=O)c1ccc(cc1)O)OC

1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one

(-20℃)

With Ice Pack

≥ 2 years