Fluorometholone Acetate ( AI3-52814, Flarex, Fluorometholone acetate | U 17,323 )

产品货号. M17725 CAS No. 3801-06-7

醋酸氟米龙是一种合成皮质类固醇，用于治疗类固醇反应性眼部炎症。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
25MG	￥269	有现货
50MG	￥423	有现货
100MG	￥597	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥121	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Fluorometholone Acetate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

醋酸氟米龙是一种合成皮质类固醇，用于治疗类固醇反应性眼部炎症。
产品描述

Fluorometholone acetate is an anti-inflammatory that may be useful in the reduction of ocular inflammation.(In Vitro):For Fluorometholone acetate, a Ki value from Lineweaver-Burk plots is obtained as 1.044 μM (noncompetitive) for hCA-I and 9.98 μM (non-competitive) for hCA-II.(In Vivo):Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension.
体外实验

For Fluorometholone acetate, a Ki value from Lineweaver-Burk plots is obtained as 1.044 μM (noncompetitive) for hCA-I and 9.98 μM (non-competitive) for hCA-II.
体内实验

Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension.
同义词

AI3-52814, Flarex, Fluorometholone acetate | U 17,323
通路

Endocrinology/Hormones
靶点

Estrogen Receptor/ERR
受体

Glucocorticoid Receptor
研究领域

Inflammation/Immunology
适应症

——

化学信息

CAS Number

3801-06-7
分子量

418.5
分子式

C24H31FO5
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (238.95 mM)
SMILES

[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)C[C@]([H])(O)[C@@]1(F)[C@@]2([H])C[C@]([H])(C)C2=CC(=O)C=C[C@]12C
化学全称

9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 17-acetate