Fangchinoline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Fangchinoline 从 Stephania tetrandra 中分离出来的，具有广泛的生物学活性，例如增强免疫力，消炎杀菌和抗动脉粥样硬化。Fangchinoline 是新型 HIV-1 抑制剂，通过损害 gp160 蛋白水解过程来抑制 HIV-1 复制。Fangchinoline 靶向 Focal adhesion kinase (FAK) 并抑制肿瘤细胞中 FAK 介导的的信号传导途径。Fangchinoline 诱导膀胱癌的凋亡 (apoptosis) 和适应性自噬 (autophagy)。

Fangchinoline is extracted from Stephania tetrandra S. Moore.(In Vitro):Fangchinoline (2.5-40 μM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 μM (24 h), 12.0 μM (48 h) and 7.57 μM (72 h), and 11.9 μM (24 h), 9.92 μM (48 h) and 7.13 μM (72 h) in 5637 cells.Fangchinoline (5 μM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3.

Fangchinoline (2.5-40 μM; 24-96 hours) inhibits both T24 and 5637 cells in dose-dependent manner, the IC50 values of Fangchinoline in T24 cells are 19.0 μM (24 h), 12.0 μM (48 h) and 7.57 μM (72 h), and 11.9 μM (24 h), 9.92 μM (48 h) and 7.13 μM (72 h) in 5637 cells.Fangchinoline (5 μM; 24 hours) induces a significant increase in the LC3-II/LC3-I ratio and a decrease in p62 in both T24 and 5637 cells, and causes a significant increase in the cleavage of caspase-3. Cell Viability AssayCell Line:T24 and 5637 cells Concentration:2.5 μM; 5 μM; 10 μM; 20 μM; 30 μM; 40 μM Incubation Time:24 hours; 48 hours; 96 hours Result:Inhibited both T24 and 5637 cells proliferation.Western Blot Analysis Cell Line:T24 and 5637 cells Concentration:5 μM Incubation Time:24 hours Result:Incresed LC3-II/LC3-I ratio and the cleavage of caspase-3.

——

——

Neuroscience

GluR

FAK

Others-Field

——

436-77-1

608.72

C37H40N2O6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (82.14 mM)

O1c2c3[C@@H](N(CCc3cc(OC)c2O)C)Cc2cc(Oc3ccc(C[C@@H]4N(CCc5c4cc1c(OC)c5)C)cc3)c(OC)cc2

——

(-20℃)

With Ice Pack

≥ 2 years