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palovarotene
CAS No. 410528-02-8
palovarotene ( RO-3300074 | RO 3300074 | RO3300074 | R-667 )
产品货号. M17504 CAS No. 410528-02-8
Palovarotene 是核视黄酸受体 γ (RAR-γ) 的激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥588 | 有现货 |
|
| 10MG | ￥938 | 有现货 |
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| 25MG | ￥1655 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥538 | 有现货 |
|
生物学信息
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产品名称palovarotene
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Palovarotene 是核视黄酸受体 γ (RAR-γ) 的激动剂。
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产品描述Palovarotene, also known as RO-3300074 and R-667, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Emphysema is characterized by the destruction of alveoli and alveolar ducts within the lungs. Retinoid signaling is believed to play a role in alveologenesis, with the retinoic acid receptor gamma thought to be required for alveolar formation.
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体外实验——
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体内实验——
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同义词RO-3300074 | RO 3300074 | RO3300074 | R-667
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通路Angiogenesis
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靶点c-Met/HGFR
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受体RARγ
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研究领域Others-Field
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适应症——
化学信息
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CAS Number410528-02-8
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分子量414.55
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分子式C27H30N2O2
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纯度>98% (HPLC)
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溶解度DMSO : 19.5 mg/mL. 47.04 mM;
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SMILESO=C(O)c1ccc(cc1)/C=C/c3cc4c(cc3Cn2cccn2)C(C)(C)CCC4(C)C
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化学全称4-((1E)-2-(5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl)benzoic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.
