AM281 ( AM281 | AM 281 | AM-281 )

产品货号. M17418 CAS No. 202463-68-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AM281
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AM 281 是一种大麻素拮抗剂，可降低大鼠盲肠结扎和穿刺后的神经功能障碍和死亡率。
产品描述

AM281 is a synthetic cannabinoid CB1 receptor antagonist.
体外实验

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体内实验

Animal Model:Male NMRI mice with the weight of 25-30 gDosage:0.62, 1.25 and 2.5 mg/kg (chronic administration); 2.5, 5 and 10 mg/kg (acute administration) Administration:Administrated i.p. every day concurrently with morphine except the day of experiment (chronic administration); Singly injected 40 min before second trial (acute administration)Result:The simultaneous daily administration of AM281 with morphine significantly shortened the exploration time, as compared with morphine-dependent mice receiving vehicle. Acute administration at a dose of 5 mg/kg, significantly augmented recognition index.
同义词

AM281 | AM 281 | AM-281
通路

Microbiology/Virology
靶点

HCV
受体

CB
研究领域

——
适应症

——

CAS Number

202463-68-1
分子量

557.21
分子式

C21H19Cl2IN4O2
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 7.14 mg/mL (12.81 mM)
SMILES

Ic1ccc(c2n(nc(c2C)C(=O)NN2CCOCC2)c2c(Cl)cc(Cl)cc2)cc1
化学全称

1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholin-4-ylpyrazole-3-carboxamide