JNK-IN-7

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JNK-IN-7 是一种选择性 JNK1/2/3 抑制剂 (IC50: 1.54/1.99/0.75 nM)。它还可以抑制 c-Jun 的磷酸化，c-Jun 是 JNK 激酶的底物。

JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.(In Vitro):JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.

JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1(IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.

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JNK-IN-7 | JNK inhibitor | JNKIN7 | JNK IN 7

Others

Other Targets

JNK1| JNK2| JNK3

Inflammation/Immunology

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1408064-71-0

493.56

C28H27N7O2

>98% (HPLC)

DMSO : 33.33 mg/mL. 67.53 mM; H2O : < 0.1 mg/mL

C(=O)(Nc1cccc(c1)C(=O)Nc1ccc(cc1)Nc1nccc(n1)c1cnccc1)/C=C/CN(C)C

3-[[(E)-4-(Dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

(-20℃)

With Ice Pack

≥ 2 years