SBE 13 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SBE13 盐酸盐是一种有效且特异性的 PLK1 抑制剂 (IC50: 0.2 nM)；对 Aurora A 激酶、Plk2/3 没有抑制作用。

SBE-13 is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2 respectively).

SBE13 significantly reduce cell proliferation and induce apoptosis in HeLa cells, with an EC50 of 18?μM. SBE13 (1-100 μM) shows no effect on Caspase 3/7 activity in NIH-3T3 cells. SBE13 (66 and 100 μM) does not change morphology after treatment of primary cells. SBE13 (10 and 100 μM) reduces pRb staining in primary cells, and this indicates a G0/G1 arrest. SBE13 (66 and 100 μM) increases levels of cyclin B1, phospho histone H3, Wee1, Emi1 and securin, and results in cleavage of Cdc27 in HeLa cells. SBE13 (10 and 100 μM) also induces apoptosis of HeLa cells.

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SBE13 | SBE 13 | SBE13 | SBE-13 HCl

Others

Other Targets

PLK1| PLK2| PLK3

Cancer

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1052532-15-6

479.4

C24H28Cl2N2O4

>98% (HPLC)

DMSO : ≥ 42 mg/mL; 87.61 mM

Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl

N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride

(-20℃)

With Ice Pack

≥ 2 years