SBE 13 hydrochloride ( SBE13 | SBE 13 | SBE13 | SBE-13 HCl )

产品货号. M17781 CAS No. 1052532-15-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SBE 13 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SBE13 盐酸盐是一种有效且特异性的 PLK1 抑制剂 (IC50: 0.2 nM)；对 Aurora A 激酶、Plk2/3 没有抑制作用。
产品描述

SBE-13 is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2 respectively).
体外实验

SBE13 significantly reduce cell proliferation and induce apoptosis in HeLa cells, with an EC50 of 18?μM. SBE13 (1-100 μM) shows no effect on Caspase 3/7 activity in NIH-3T3 cells. SBE13 (66 and 100 μM) does not change morphology after treatment of primary cells. SBE13 (10 and 100 μM) reduces pRb staining in primary cells, and this indicates a G0/G1 arrest. SBE13 (66 and 100 μM) increases levels of cyclin B1, phospho histone H3, Wee1, Emi1 and securin, and results in cleavage of Cdc27 in HeLa cells. SBE13 (10 and 100 μM) also induces apoptosis of HeLa cells.
体内实验

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同义词

SBE13 | SBE 13 | SBE13 | SBE-13 HCl
通路

Others
靶点

Other Targets
受体

PLK1| PLK2| PLK3
研究领域

Cancer
适应症

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CAS Number

1052532-15-6
分子量

479.4
分子式

C24H28Cl2N2O4
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 42 mg/mL; 87.61 mM
SMILES

Clc1ncc(COc2c(OC)cc(CNCCc3cc(OC)c(OC)cc3)cc2)cc1.Cl
化学全称

N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride