TUG-891 ( TUG-891 | TUG 891 | TUG891 )

产品货号. M17264 CAS No. 1374516-07-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

TUG-891
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TUG-891 是一种在肠道、脂肪细胞和促炎巨噬细胞中表达的 G 蛋白偶联受体 (GPCR)，可被长链游离脂肪酸激活。
产品描述

TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.
体外实验

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.
体内实验

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同义词

TUG-891 | TUG 891 | TUG891
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

GPR120
研究领域

Metabolic Disease
适应症

——

CAS Number

1374516-07-0
分子量

364.41
分子式

C23H21FO3
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 180 mg/mL 493.95 mM
SMILES

c1(c(ccc(c1)F)c1ccc(cc1)C)COc1ccc(cc1)CCC(=O)O
化学全称

3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid

1.Hopkins MM, Zhang Z, Liu Z, Meier KE. J Clin Med. 2016 Jan 26;5(2).

计算器

产品手册

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