MLN2480 ( TAK-580, TAK 580, TAK580, MLN 2480, MLN-2480, MLN2480 )

产品货号. M17143 CAS No. 1096708-71-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MLN2480
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MLN2480 是一种处于临床试验阶段的口服选择性泛 Raf 激酶抑制剂。
产品描述

TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.
体外实验

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体内实验

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同义词

TAK-580, TAK 580, TAK580, MLN 2480, MLN-2480, MLN2480
通路

TGF-beta/Smad
靶点

TGFBR
受体

Raf
研究领域

Cancer
适应症

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CAS Number

1096708-71-2
分子量

506.29
分子式

C17H12Cl2F3N7O2S
纯度

>98% (HPLC)
溶解度

DMSO : 50 mg/mL 98.76 mM;
SMILES

Nc1ncnc(C(=O)N[C@H](C)c2ncc(C(=O)Nc3ncc(Cl)c(C(F)(F)F)c3)s2)c1Cl
化学全称

(R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide