Kartogenin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Kartogenin 是 smad4/smad5 通路的激活剂，促进多能间充质干细胞选择性分化为软骨细胞。

Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.

Kartogenin (50-5000 nM; 2 weeks) induces the chondrogenetic differentiation of the BMSCs in a concentration-dependent manner.Kartogenin (100 nM; 72 h) induces chondrocyte nodule formation in primary hMSCs. Kartogenin (10 nM-10 μM; 72 h) increases chondrocyte-specific gene expression in hMSCs.Kartogenin (0.12-10 μM; 48 h) inhibits nitric oxide (NO) and glycosaminoglycan (GAG) release induced by cytokines in primary bovine articular chondrocytes.

Kartogenin (10 μM in 4μL of saline; i.a. on days 7 and 21) promotes cartilag erepair in collagenase VII-induced OA models in mice.

2(Biphenyl4yl)carbamoylbenzoic acid 4Phenylphthalanilic acid (8CI) KGN

TGF-beta/Smad

TGFBR

Smad4| Smad5

Other Indications

——

4727-31-5

317.34

C20H15NO3

>98% (HPLC)

Ethanol: 18 mg/mL warmed (56.72 mM); DMSO: 63 mg/mL (198.52 mM)

O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O

2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid

(-20℃)

With Ice Pack

≥ 2 years