PV-1019 ( NSC-744039 | NSC744039 | PV1019 )

产品货号. M16921 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PV-1019
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种有效的 ATP 竞争性高选择性 Chk2 抑制剂，IC50 为 138 nM。
产品描述

A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM; displays much reduced or no activity against a panel of 52 other cellular kinases, including Chk1; inhibits Chk2-mediated phosphorylation of Cdc25C (IC50=260 nM), and nd HDMX degradation in response to DNA damage; protects normal mouse thymocytes against ionizing radiation-induced apoptosis.
体外实验

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体内实验

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同义词

NSC-744039 | NSC744039 | PV1019
通路

Angiogenesis
靶点

Chk
受体

Chk
研究领域

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适应症

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CAS Number

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分子量

379.38
分子式

C18H17N7O3
纯度

>98% (HPLC)
溶解度

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SMILES

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化学全称

7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide