Silvestrol aglycone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Silvestrol 是一种来自 Aglaia foveolata 的潜在抗癌 rocaglate 衍生物，通过线粒体/凋亡体途径诱导癌细胞凋亡。

Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway; effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells; demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.

Silvestrol aglycone (Compound 4) inhibits the proliferation of MDA-MB-231 cells with an E50 of 20 ± 10 nM after 72 h.

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Apoptosis

Apoptosis

Apoptosis

Cancer

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960365-65-5

478.49

C27H26O8

>98% (HPLC)

10 mM in DMSO

COC1=CC=C(C=C1)C23C(C(C(C2(C4=C(O3)C=C(C=C4OC)O)O)O)C(=O)OC)C5=CC=CC=C5

1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-

(-20℃)

With Ice Pack

≥ 2 years