Diminazene Aceturate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Diminazene，也称为 Diminazine、4,4'-(重氮氨基)苯甲脒、4,4'-(1-三氮烯-1,3-二基)双苯甲脒酰胺、Diminazine aceturate 或 Diminazene aceturate，是一种杀锥虫剂。

Diminazene, also known as Diminazine, 4,4’-(Diazoamino)benzamidine, 4,4’-(1-Triazene-1,3-diyl)bis-benzenecarboximidamide, Diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a solid. This compound belongs to the phenylhydrazines. These are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group. Known drug targets of diminazene include HTH-type transcriptional regulator QacR, trypsin-1, amiloride-sensitive amine oxidase [copper-containing], and mitochondrial peroxiredoxin-5.

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Animal Model:Female BALB/c mice and C57BL/6 mice (6-8 week old) infected with T. congolense variant antigenic type TC1 Dosage:14 mg/kg Administration:Intraperitoneal injection Result:Significantly reduced the percentages of CD25+ cells, a concomitant reduction in the percentage of regulatory (CD4+Foxp3+) T cells and a striking reduction in serum levels of disease exacerbating pro-inflammatory cytokines including IL-6, IL-12, TNF and IFN-γ.

Diminazene diaceturate

Others

Other Targets

Peroxiredoxin-5| QacR| Trypsin-1

Other Indications

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908-54-3

515.52

C22H29N9O6

>98% (HPLC)

Water: 100 mg/mL (193.97 mM); DMSO: 19 mg/mL (36.85 mM)

N=C(C1=CC=C(N/N=N/C2=CC=C(C(N)=N)C=C2)C=C1)N.O=C(C)NCC(O)=O.O=C(C)NCC(O)=O

4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzene-carboximidamide Diaceturate

(-20℃)

With Ice Pack

≥ 2 years