GW-870086

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GW-870086 是一种有效的抗炎剂。 GW-870086 还在糖皮质激素受体激动剂中发挥作用（在表达 NF-κB 的 A549 细胞中 pIC50：10.1）。

GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB). GW-870086 (10-100 nM) obviously increases fibronectin secretion. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). GW-870086 displays no effect on the MMTV reporter genes in A549 cells and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor, or androgen receptor. GW-870086 also has no effect on MMP2 secretion and does not enhance cellular myocilin.

GW-870086 a glucocorticoid receptor agonist, inhibits NFkB reporter gene with a pIC50 of 10.1, but shows no effect on the MMTV reporter genes in A549 cells, and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). GW-870086 (GW870086X; 10-100 nM) significantly increases fibronectin secretion. However, GW-870086 has no effect on MMP2 secretion, and does not increase cellular myocilin.

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Others

Other Targets

glucocorticoid receptor

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827319-43-7

559.64

C31H39F2NO6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (178.69 mM)

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(-20℃)

With Ice Pack

≥ 2 years