AMG1 ( AMG 1 | AMG-1 )

产品货号. M16497 CAS No. 903591-53-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AMG1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种新型特异性 CRAC 通道抑制剂，可阻断效应器功能。
产品描述

A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.
体外实验

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体内实验

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同义词

AMG 1 | AMG-1
通路

GPCR/G Protein
靶点

Calcium Channel
受体

Calcium Channel
研究领域

——
适应症

——

CAS Number

903591-53-7
分子量

413.732
分子式

C18H9ClF5N3O
纯度

>98% (HPLC)
溶解度

——
SMILES

C1=CC(=C(C(=C1)F)C(=O)NC2=NC=C(N=C2)C3=C(C=CC(=C3)C(F)(F)F)Cl)F
化学全称

N-(5-(2-chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamid

1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.

计算器

产品手册

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