Vismodegib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vismodegib(GDC-0449) 是一种更有效的新型、特异性合成口服刺猬通路抑制剂，IC50 为 3 nM；还抑制 P-gp，IC50 为 3.0 μM。

Vismodegib(GDC-0449) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM; also inhibits P-gp with IC50 of 3.0 μM.(In Vitro):Vismodegib (HhAntag691) is an ABCG2 inhibitor and can increase the effective intracellular concentration of NSC 279836, another ABCG2 substrate, through blocking its export in HEK293 cells. Vismodegib (HhAntag691, 10 μM), resensitizes MDCKII/Pgp cells and MDCKII/MRP1 cells to NSC757 treatment. Vismodegib (25 μM or 50 μM) concentration dependently inhibits HCC and H1339 cells.(In Vivo):Vismodegib is a novel small molecule HPI, often used for clinical trials. Vismodegib (0.3 to 75 mg/kg, p.o.) is highly efficacious in medulloblastoma allograft tumors. Vismodegib (> 46 mg/kg, p.o.) causes growth delay in patient-derived colorectal xenografts.

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GDC-0449

GPCR/G Protein

Hedgehog (Hh)

Hedgehog

Cancer

Skin Cancer

879085-55-9

421.3

C19H14Cl2N2O3S

>98% (HPLC)

DMSO: 84 mg/mL (199.38 mM)

O=C(NC1=CC=C(Cl)C(C2=NC=CC=C2)=C1)C3=CC=C(S(=O)(C)=O)C=C3Cl

2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years