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AZD-1305
CAS No. 872045-91-5
AZD-1305 ( AZD1305 )
产品货号. M16340 CAS No. 872045-91-5
AZD-1305 是一种新型抗心律失常药，主要阻断 Ikr 的快速成分。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1482 | 有现货 |
|
| 10MG | ￥2119 | 有现货 |
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| 25MG | ￥3227 | 有现货 |
|
| 50MG | ￥4511 | 有现货 |
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| 100MG | ￥6003 | 有现货 |
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| 200MG | ￥8064 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1634 | 有现货 |
|
生物学信息
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产品名称AZD-1305
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AZD-1305 是一种新型抗心律失常药，主要阻断 Ikr 的快速成分。
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产品描述AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes; significantly prolongs action potential duration and reduces excitability at 0.1-10 uM in dogs, effectively prevents induction of persistent acetylcholine-mediated atrial fibrillation (AF) in vivo.Heart Arrhythmia Phase 1 Discontinued.
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体外实验——
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体内实验——
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同义词AZD1305
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通路Membrane Transporter/Ion Channel
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靶点Sodium Channel
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受体Sodium Channel
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研究领域Cardiovascular Disease
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适应症Heart Arrhythmia
化学信息
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CAS Number872045-91-5
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分子量434.512
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分子式C22H31FN4O4
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)(C)OC(=O)NCCN1C[C@@H]2CN(C[C@H](C1)O2)CCOc3ccc(cc3F)C#N
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化学全称(2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sicouri S, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):255-9.
2. Burashnikov A, et al. J Cardiovasc Pharmacol. 2010 Jul;56(1):80-90.
3. Johnson DM, et al. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):201-9.
4. Geller JC, et al. J Clin Pharmacol. 2009 Mar;49(3):312-22.
产品手册
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