Peretinoin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种新型口服合成类维生素A，具有潜在的抗肿瘤和化学预防活性。

A novel orally available, synthetic retinoid with potential antineoplastic and chemopreventive activities; inhibits DEN-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation; decreases the levels of cyclin D1, cyclin D2, cIAP2 and XIAP proteins, and inhibits growth of ATL cells both in vitro and in vivo; prevents the progression of NASH and the development of HCC through activating the autophagy pathway by increased Atg16L1 expression in mice model; also inhibits HCV replication and infectious virus release in vitro.Liver Cancer Phase 3 Clinical.

Cell Autophagy Assay Cell Line:Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line Concentration:5?μM Incubation Time:24 hours Result:Up-regulated the expression of LC3B-II and increased autophagy flux.Western Blot Analysis Cell Line:Human hepatoma (Huh-7) cells Concentration:10, 20 and 40?μM Incubation Time:12, 24, 48 and 72? hours Result:Exhibited suppressed SPHK1 expression after 24?h treatment, even at 10?μM.

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NIK-333 | NIK333 | NIK 333

Microbiology/Virology

HCV

HCV

Cancer

Liver Cancer

81485-25-8

302.451

C20H30O2

>98% (HPLC)

DMSO: ≥ 100 mg/mL; In vivo: Peretinoin is dissolved in DMSO (3 mg/mL) and then diluted with water (DMSO: water=1:1).

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/C=C/C(C)=C/C(O)=O

2,4,6,10,14-Hexadecapentaenoic acid, 3,7,11,15-tetramethyl-, (2E,4E,6E,10E)-

(-20℃)

With Ice Pack

≥ 2 years