Cisapride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

西沙必利是一种促胃动力剂，是一种增加上胃肠道动力的化合物。

Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system.

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Animal Model:Male Wistar rats with trinitrobenzenesulfonic-acid-(TNBS) induced rat colitis Dosage:2 mg/kg (i.p.); 4 mg/kg, (oral administration)Administration:2 mg/kg, intraperitoneal injection ; 4 mg/kg, oral administration; once Result:Showed severe and intense transmural inflammation and diffuse necrosis, inflammatory granulomas and submucosal neutrophils infiltration in colitis rat. Induced body weight loss.

Kaudalit | Kinestase | Prepulsid | Presid | Pridesia | Propulsid

Endocrinology/Hormones

5-HT Receptor

5-HT| Potassium Channel

Neurological Disease

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81098-60-4

465.95

C23H29ClFN3O4

>98% (HPLC)

Water: 2.71 mg/L

O=C(N[C@H]1[C@@H](OC)CN(CCCOC2=CC=C(F)C=C2)CC1)C3=CC(Cl)=C(N)C=C3OC

Benzamide, 4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxy-4-piperidinyl)-2-methoxy-, cis-

(-20℃)

With Ice Pack

≥ 2 years