Trequinsin hydrochloride ( HL 725 )

产品货号. M15958 CAS No. 78416-81-6

Trequinsin 盐酸盐 (HL 725) 是一种有效的、细胞渗透性的、口服活性的 cGMP 抑制的磷酸二酯酶抑制剂 (PCE3 IC50=250 pM)。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥759	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Trequinsin hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Trequinsin 盐酸盐 (HL 725) 是一种有效的、细胞渗透性的、口服活性的 cGMP 抑制的磷酸二酯酶抑制剂 (PCE3 IC50=250 pM)。
产品描述

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM; reduces systemic blood pressure in both normotensive and hypertensive animal models.Hypertension Discontinued.
体外实验

Trequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities.Trequinsin hydrochloride is an efficacious agonist of [Ca2+]i. Cell Viability Assay Cell Line:Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria.Concentration:10 μM.Incubation Time:20 min.Result:Caused a concentration dependent increase in [Ca2+]i (EC50 = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]).
体内实验

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同义词

HL 725
通路

Angiogenesis
靶点

PDE
受体

PDE
研究领域

Cardiovascular Disease
适应症

Hypertension

化学信息

CAS Number

78416-81-6
分子量

441.956
分子式

C24H28ClN3O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 62.5 mg/mL (141.42 mM)
SMILES

CC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2C)OC)OC)C.Cl
化学全称

2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Lal B, et al. J Med Chem. 1984 Nov;27(11):1470-80. 2. Ruppert D, et al. Life Sci. 1982 Nov 8;31(19):2037-43. 3. Darius H, et al. Br J Pharmacol. 1985 Mar;84(3):735-41. 4. Blaskó G, et al. Thromb Res. 1986 Jul 15;43(2):249-50.

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