Zalcitabine ( ddC | Dideoxycytidin )

产品货号. M15852 CAS No. 7481-89-2

一种嘧啶类似物逆转录酶抑制剂 (NRTI)，用于治疗 HIV/AIDS。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
25MG	￥241	有现货
50MG	￥325	有现货
100MG	￥492	有现货
200MG	￥705	有现货
500MG	￥1197	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥371	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Zalcitabine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种嘧啶类似物逆转录酶抑制剂 (NRTI)，用于治疗 HIV/AIDS。
产品描述

A pyrimidine analog reverse transcriptase inhibitor (NRTI) for the treatment of HIV/AIDS; also incorporates into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group; highly oral activity.HIV Infection Approved(In Vitro):Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.
体外实验

Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.
体内实验

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同义词

ddC | Dideoxycytidin
通路

Microbiology/Virology
靶点

HIV
受体

HIV
研究领域

Infection
适应症

HIV Infection