BMS-707035 ( BMS 707035 | BMS707035 )

产品货号. M15791 CAS No. 729607-74-3

BMS-707035 是一种有效、特异性和可逆的 HIV-1 整合酶 (IN) 抑制剂，可阻断 HIV IN 链转移活性，IC50 为 15 nM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥464	有现货
10MG	￥755	有现货
25MG	￥1460	有现货
50MG	￥2465	有现货
100MG	￥3357	有现货
200MG	￥4788	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥416	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

BMS-707035
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BMS-707035 是一种有效、特异性和可逆的 HIV-1 整合酶 (IN) 抑制剂，可阻断 HIV IN 链转移活性，IC50 为 15 nM。
产品描述

BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM.HIV Infection Phase 2 Discontinued.
体外实验

BMS-707035 has antiviral activity with EC50 values of 2 nM and 17 nM in the presence of 10% FBS and 15 mg/mL human serum albumin, respectively.BMS-707035 has high plasma protein binding and not overtly cytotoxicy to several cell lines, with CC50 value of ≥45 μM.BMS-707035 has a relatively weak CYP inhibiton with IC50 value of ≥40 μM.
体内实验

BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species.Pharmacokinetic Parameters of BMS-707035 in rat, dog and monkey (IV).
同义词

BMS 707035 | BMS707035
通路

Microbiology/Virology
靶点

HIV
受体

HIV-Iintegrase
研究领域

Infection
适应症

HIV Infection

化学信息

CAS Number

729607-74-3
分子量

410.42
分子式

C17H19FN4O5S
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

Cn1c(=O)c(c(nc1N2CCCCS2(=O)=O)C(=O)NCc3ccc(cc3)F)O
化学全称

4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Dicker IB, et al. J Biol Chem. 2007 Oct 26;282(43):31186-96. 2. Langley DR, et al. Biochemistry. 2008 Dec 23;47(51):13481-8. 3. Al-Mawsawi LQ, et al. Expert Opin Emerg Drugs. 2008 Jun;13(2):213-25.

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