PD 404182

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PD 404182 (PD404182, PD-404182) 是一种杂环亚氨基苯并噻嗪衍生物，具有抗菌和抗炎特性，是人 DDAH1 活性的有效抑制剂 (IC50=9 uM)，并提高细胞 ADMA 水平。

PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels; significantly increases intracellular levels of ADMA and reduces LPS-induced NO production in cultured primary human vascular endothelial cells (ECs), abrogates the formation of tube-like structures by ECs in in vitro angiogenesis assay; also shows anti-HIV and anti-HSV activites.Bacterial Infection Discontinued.

PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs.PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity.PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM.PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora. Cell Viability Assay Cell Line:Human dermal microvascular endothelial cells (ECs)Concentration:10-300 μM Incubation Time:24 hours Result:Did not induce cytotoxicity.

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PD404182 | PD-404182

Microbiology/Virology

HIV

HIV

Infection

Bacterial Infection

72596-74-8

217.29

C11H11N3S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (230.11 mM)

N=C1SC2=CC=CC=C2C3=NCCCN13

6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine

(-20℃)

With Ice Pack

≥ 2 years